We hope to translate what we learn from our direct recordings and stimulation
to clinical populations that are affected by memory impairments
or who have dysfunction in the neural circuits that support memory.
Interested in more information about Alzheimer’s disease?
We are working with Dr. Andres Lozano and Drs. Chakravarty, Lerch, and Williams on our Brain Canada team to develop stimulation treatments to alleviate the memory impairments associated with Alzheimer’s disease.
We’ve also recently partnered up with Dr. Matt Huentelman from TGen, to see if our memory task will be useful in early diagnostics and/or as a sensitive assay in the progression of Alzheimer’s disease. If you haven’t taken their test yet, it’s surprisingly simple – go check it out. We are grateful for the support from the Alzheimer’s Association, the Alzheimer’s Society, the Krembil Foundation and Brain Canada.
Interested in more information about epilepsy?
We are working with Dr. Taufik Valiante and Dr. Milos Popovic to better understand what types of synchronous activity in the medial temporal lobe support memory, and what types are ‘pathological’ in mesial temporal lobe epilepsy. Ultimately, we hope to use this information find effective ways to interrupt the propagation of seizures from the hippocampus and adjacent structures while otherwise preserving functional dynamics. Thanks for the support from the Krembil Foundation and Brain Canada.
We are also interested in comorbitiy in Alzheimer’s disease and Temporal Lobe Epilepsy (see, for example, the work of the Mucke lab and the Scharfman lab). We hope to better understand the changes with learning that occur in the hippocampus, entorhinal cortex, and other ‘handshake’ regions in the Delay-Brion circuit and temporal lobe.